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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name hsa-miR-124a
ncRNA Category miRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line UM samples and their adjacent uveal tissue counterparts; human UM cell lines M17, M21, M23 and SP6.5
Methods qRT-PCR, methylation-specific PCR, CHIP assay, flow cytometry, transwell assay, Matrigel invasion assay, luciferase reporter assay, Western blot
Expression pattern down-regulated
Functional description miR-124a could function as a potent tumor suppressor by regulation of multiple targets, and was epigenetically silenced in the development of uveal melanoma.
PubMed ID 23404119
Year 2013
Title MicroRNA-124a is epigenetically regulated and acts as a tumor suppressor by controlling multiple targets in uveal melanoma.
Drug-related ncRNA NO

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